John Q Trojanowski Selected Research

Amyloid Plaque

1/2022	Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques.
1/2021	ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration.
11/2020	Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease.
10/2020	Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition.
1/2020	Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
1/2020	Detection of Alzheimer Disease Pathology in Patients Using Biochemical Biomarkers: Prospects and Challenges for Use in Clinical Practice.
1/2020	Defining and predicting transdiagnostic categories of neurodegenerative disease.
1/2019	Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review.
1/2018	Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation.
1/2017	Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis.

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John Q Trojanowski Research Topics

Disease

287	Alzheimer Disease (Alzheimer's Disease) 10/2022 - 02/2002
115	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2022 - 05/2002
106	Parkinson Disease (Parkinson's Disease) 01/2022 - 02/2002
98	Cognitive Dysfunction 10/2022 - 01/2002
94	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2022 - 05/2005
80	Dementia (Dementias) 01/2022 - 06/2002
80	Tauopathies 01/2022 - 05/2002
72	Frontotemporal Dementia (Semantic Dementia) 01/2022 - 05/2003
54	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2021 - 11/2004
52	Synucleinopathies 01/2022 - 05/2002
42	Atrophy 01/2022 - 11/2003
34	Amyloid Plaque 01/2022 - 11/2002
25	Disease Progression 01/2022 - 02/2004
16	Amyloidosis 01/2020 - 07/2002
15	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2019 - 09/2004
14	TDP-43 Proteinopathies 01/2018 - 07/2007
13	Proteostasis Deficiencies 01/2022 - 11/2011
13	Corticobasal Degeneration 11/2019 - 06/2002
13	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2019 - 05/2005
11	Traumatic Brain Injuries (Traumatic Brain Injury) 06/2022 - 01/2003
11	Multiple System Atrophy 01/2021 - 12/2002
9	Pick Disease of the Brain (Pick's Disease) 01/2021 - 06/2002
9	Parkinsonian Disorders (Parkinsonism) 01/2019 - 11/2003
8	Inflammation (Inflammations) 01/2022 - 03/2004
7	Lewy Body Disease (Lewy Body Dementia) 01/2021 - 07/2011
7	Movement Disorders (Movement Disorder) 01/2019 - 05/2002
6	Gliosis 01/2022 - 12/2002
6	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2020 - 09/2013
6	Hippocampal Sclerosis 09/2014 - 12/2011
5	Neuroinflammatory Diseases 01/2020 - 02/2007
5	Neoplasms (Cancer) 01/2020 - 08/2003
5	Central Nervous System Diseases (CNS Diseases) 01/2017 - 05/2002
5	Wounds and Injuries (Trauma) 06/2014 - 08/2004
4	Tremor (Tremors) 01/2022 - 05/2006
4	Memory Disorders (Memory Loss) 06/2021 - 04/2005
4	Down Syndrome (Down's Syndrome) 01/2020 - 11/2002
4	Brain Injuries (Brain Injury) 11/2015 - 08/2004
3	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 06/2022 - 06/2014
3	limbic-predominant age-related TDP-43 encephalopathy 01/2022 - 01/2019
3	Brain Diseases (Brain Disorder) 01/2022 - 04/2013
3	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 11/2020 - 01/2006

Drug/Important Bio-Agent (IBA)

172	Biomarkers (Surrogate Marker)IBA 10/2022 - 07/2003
114	Amyloid (Amyloid Fibrils)IBA 10/2022 - 11/2002
110	Proteins (Proteins, Gene)FDA Link 06/2022 - 02/2002
61	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2022 - 07/2007
53	alpha-SynucleinIBA 10/2022 - 02/2002
47	Amyloid beta-PeptidesIBA 06/2022 - 05/2002
46	SynucleinsIBA 01/2022 - 05/2002
46	tau Proteins (tau Protein)IBA 10/2021 - 06/2002
34	Apolipoproteins E (ApoE)IBA 01/2022 - 03/2010
31	Pharmaceutical PreparationsIBA 01/2018 - 02/2002
26	UbiquitinIBA 12/2017 - 12/2002
22	Peptides (Polypeptides)IBA 01/2020 - 12/2002
18	ProgranulinsIBA 12/2018 - 03/2007
17	ApolipoproteinsIBA 06/2022 - 10/2006
15	AntibodiesIBA 01/2020 - 06/2002
14	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 10/2003
12	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 06/2022 - 11/2004
11	Biological ProductsIBA 11/2021 - 08/2010
11	Phosphotransferases (Kinase)IBA 01/2021 - 12/2005
11	Protein Isoforms (Isoforms)IBA 01/2020 - 06/2002
10	florbetapirIBA 10/2020 - 01/2013
10	Carrier Proteins (Binding Protein)IBA 12/2019 - 01/2005
9	EnzymesIBA 10/2019 - 12/2002
8	Monoclonal AntibodiesIBA 11/2020 - 11/2003
8	Excipients (Suspending Agents)IBA 09/2017 - 08/2012
7	Leucine (L-Leucine)FDA Link 01/2021 - 02/2006
7	Protein AggregatesIBA 04/2015 - 01/2004
7	Threonine (L-Threonine)FDA Link 02/2015 - 04/2009
6	PrionsIBA 01/2022 - 05/2012
6	Apolipoprotein E4IBA 10/2020 - 05/2005
6	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 10/2011
6	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 10/2015 - 05/2010
5	thioflavin TIBA 11/2019 - 04/2005
5	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2019 - 05/2008
5	Dopamine (Intropin)FDA LinkGeneric 11/2017 - 06/2005
5	Complement System Proteins (Complement)IBA 01/2017 - 05/2003
5	amyloid beta-protein (1-42)IBA 02/2015 - 04/2009
5	Valosin Containing ProteinIBA 12/2010 - 07/2007
5	IsoprostanesIBA 08/2010 - 01/2002
4	LipidsIBA 01/2021 - 01/2019
4	LigandsIBA 01/2020 - 09/2013
4	Messenger RNA (mRNA)IBA 12/2019 - 07/2002
4	ImmunosorbentsIBA 10/2019 - 09/2011
4	desoxyepothilone B (epothilone D)IBA 09/2016 - 10/2010
4	Amino Acids FDA Link 12/2015 - 12/2010
4	polyglutamineIBA 11/2015 - 01/2004
4	Blood Proteins (Serum Proteins)IBA 10/2015 - 08/2012
4	Paclitaxel (Taxol)FDA LinkGeneric 04/2011 - 07/2007
3	IronIBA 01/2022 - 05/2006
3	RNA (Ribonucleic Acid)IBA 01/2021 - 03/2014
3	Prion ProteinsIBA 11/2020 - 04/2013
3	Glucosylceramidase (Glucocerebrosidase)IBA 01/2020 - 06/2013
3	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2020 - 01/2017
3	flutemetamolIBA 11/2018 - 11/2011

Therapy/Procedure

41	Therapeutics 01/2020 - 04/2002
8	Injections 11/2020 - 02/2015
5	Immunotherapy 01/2021 - 01/2015
4	Transplantation 05/2008 - 04/2003
3	Activities of Daily Living (ADL) 01/2021 - 04/2016